Last edited by Mikasar
Thursday, May 14, 2020 | History

8 edition of Therapeutic applications of ribozymes found in the catalog.

Therapeutic applications of ribozymes

  • 250 Want to read
  • 4 Currently reading

Published by Humana Press in Totowa, N.J .
Written in English

    Subjects:
  • Catalytic RNA -- Therapeutic use,
  • Catalytic RNA -- Laboratory manuals,
  • RNA, Catalytic -- therapeutic use,
  • Gene Therapy -- methods

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Kevin J. Scanlon.
    SeriesMethods in molecular medicine ;, 11
    ContributionsScanlon, Kevin J., 1947-
    Classifications
    LC ClassificationsRM666.R554 T47 1998
    The Physical Object
    Paginationxiv, 462 p. :
    Number of Pages462
    ID Numbers
    Open LibraryOL361399M
    ISBN 100896034771
    LC Control Number98021526

    The discovery of ribozymes further supports ‘RNA world’ that is RNA can do the function of protein or catalysis. The catalytic ability of RNA may be later passed on to the proteins. The reason for catalytic activity in RNA may be due to the presence of 2’ OH group where in DNA it is 2’H. Applications Ribozymes, including hammerhead ribozymes, can be used in the study of gene function and gene therapy for diseases. Those ribozymes which are designed to target a specific gene transcript (hnRNA, mRNA) would bind and cleave the substrate RNA in vitro, or in vivo.

    Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic Implications brings together timely, authoritative reviews by renowned international leaders in the fields of ribozymes, RNA interference, DNAzymes and oligonucleotide decoys, with emphasis on biochemistry and translational research. The "tC19Z" ribozyme can add up to 95 nucleotides with a fidelity of mutations/nucleotide. Attempts have been made to develop ribozymes as therapeutic agents, as enzymes which target defined RNA sequences for cleavage, as biosensors, and for applications .

    In this definitive guide to intracellular ribozyme applications, researchers from both industry and academia review the most recent pharmaceutical, therapeutic, and biotechnological applications of ribozymes. Leading scientists from around the world present the latest principles on the application of ribozyme technology to the inhibition of gene expression in living cells.   Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. The aim of this review is to summarize recent advances observed in ribozyme- and riboswitch-based therapeutic applications that, in some cases, have reached clinical by:


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Therapeutic applications of ribozymes Download PDF EPUB FB2

The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RNA.

The ribozyme applications appearing in this book should benefit not only those experienced in ribozymes, but also those applying this ribozyme technology for the first : Hardcover.

The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RNA.

The ribozyme applications appearing in this book should benefit not only those experienced in ribozymes, but also those applying this ribozyme.

Therapeutic Applications of Ribozymes contains all the technical support needed to make ribozyme technology a widely used and significant : $ In Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the Therapeutic applications of ribozymes book of specific genes as key routes to the development of novel therapies for a wide variety of diseases.

Introduction. In Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target.

These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RNA.

The ribozyme applications appearing in this book should benefit not only those experienced in ribozymes, but also those applying this ribozyme technology for the first time. Currently, the therapeutic application of ribozymes to human diseases is limited by gene transfer systems.

It is anticipated that ribozymes ultimately will play an important role in human gene therapy. Keywordsibozyme, oncogene, cancer, antisense, gene therapy, drug resistance. CONTENTS by: Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology.

Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of Format: Capa Comum. Therapeutic applications of ribozymes Natural ribozymes perform various enzymatic reactions and are classified by their relative size [ 10, 11, 12 ].

Large ribozymes (> nt) are constituted by the group I and group II introns, and by the protein-assisted RNase P, while small nucleolytic ribozymes include the hammerhead, hairpin, hepatitis delta virus (HDV), Varkud satellite (VS), and glmS by: RIBOZYMES ARE ribonucleic acid (RNA) molecules with enzymatic activity that have a great potential as therapeutic entities because of their ability to either cleave deleterious RNAs or repair mutant cellular RNAs.

1, 2 They form basepair-specific complexes and catalyze the hydrolysis of specific phosphodiester bonds, causing RNA strand by: Therapeutic Applications of Ribozymes contains all the technical support needed to make ribozyme technology a widely used and significant methodology.

The practical applications of ribozymes range from research on gene functions to their use as potential therapeutic agents for fighting cancer and viral infections [22][23][24][25][26][27][28] [ The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RNA.

The ribozyme applications appearing in this book should benefit not only those experienced in ribozymes, Format: Hardcover. Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases.

Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology. Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of Format: Tapa dura.

The catalytic domains of these ribozymes are small and relatively well characterized, and they are more widely used in therapeutic applications. Each has characteristics that confer specific advantages and disadvantages as therapeutic by: In Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used.

Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. The aim of this review is to summarize recent advances observed in ribozyme- and riboswitch-based therapeutic applications that, in some cases, have reached clinical by:   Therapeutic Applications of Ribozymes has been compiled by the editor, Kevin Scanlon, with the goal in mind of "providing an overview of the utility of ribozymes to selectively inhibit expression Author: John Rossi.

In Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target.

These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool.

We are convinced. 2. Enzymes, Ribozymes & DNAzymes - II Edition (ISBN: ). This is an Advanced Enzymology book and discusses most of the classical and modern aspects of Enzymology in detail.

These ribozymes have cleaved the target RNAs in vitro and altered the cellular pathology. Currently, the therapeutic application of ribozymes to human diseases is limited by gene transfer systems. It is anticipated that ribozymes ultimately will play an important role in human gene by:   Investigators studying the origin of life haveproduced ribozymes in the laboratory that arecapable of catalyzing their ownsynthesis under very specific conditions, suchas an RNA polymerase ribozyme.

Some ribozymes may play an important roleas therapeutic agents, as enzymes whichtarget defined RNA sequences for cleavage,as biosensors, and for.